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May 24, 2012

Jeff Jacoby: The peace process battered Israel's reputation
Clifford D. May: What Iran's Rulers Want
Michael Muskal: 'Pro-choice' position hits record low, according to poll
Chris Farrell: Are We in a Tech Bubble?
Kimberly Lankford: Switching Medicare Advantage Plans Mid-Year
Bryan McIver, M.B., Ch.B., Ph.D.: Mayo Clinic Medical Edge: Understanding hyperthyroidism and its variety of treatment options
The Kosher Gourmet by Penelope Wall: PHILLY CHEESE STEAKS --- hold the steak!
May 23, 2012
Ex-CIA spy in Iran's Revolutionary Guard: Baghdad talks highlight Western naivete
Tony Pugh: More private colleges offering tuition discounts
Lisa Gerstner: 4 Money-Etiquette Questions Answered
Mary Beth Franklin: How to Choose the Right Annuity for You
Art Markman, Ph.D.: Get smart: How to bulk up your creativity muscles
Tina Susman: The wig wasn't enough: Man gets 13 years for posing as his dead mom
The Kosher Gourmet by Emma Christensen:A simple way to do fish right
May 22, 2012
David S. Cloud and Kathleen Hennessey: Obama changes mind on Pakistan invite to NATO summit --- and then gets dissed by country's president
Warren Richey: Can US group challenge overseas surveillance act? Supreme Court to decide
Thomas M. Anderson: Walking Away From a Mortgage
Environmental Nutrition editors: The lowdown on a low-acid diet
The Kosher Gourmet by Megan Gordon: Enjoy a celebration of the most rich and layered flavors: Black bean, sweet potato and quinoa chili
May 21, 2012
Mark Clayton: Cybersecurity: How US utilities passed up chance to protect their networks
Howard LaFranchi: NATO summit: Who will foot the bill for long-term Afghanistan security?
Chris Farrell : Earn Dividends in Emerging Markets with This WisdomTree ETF
James K. Glassman: 5 Stock Picks Among Online Retailers
Stephen Whiteside, Ph.D. : Mayo Clinic Medical Edge: Social anxiety disorder --- or just shy?
Guy Jackson : Victim's father regrets death of Lockerbie bomber
The Kosher Gourmet by Mario Batali: Famed chef's veal shoulder farsumagru: A festive meat course for late spring
May 18, 2012
Rabbi Berel Wein: Striving: The People of the Book's Book for (All of) the People
Caroline B. Glick: Embracing dangerous delusions and not our friends
Steven Goldberg: 5 Great Stock Picks and the Exchange-Traded Fund that Owns Them
Janet Bodnar: How to Teach Kids to Handle Credit Cards
Mary Pickett, M.D.: Ask the Harvard Experts: Don't be forced into gluten-free lifestyle based merely on a doctor's false-positive test
The Kosher Gourmet by Carolyn Malcoun: DIY healthy lunchbox treats: HOMEMADE FRUIT BARS for kids and brown-bagging adults alike
May 17, 2012
Warren Richey: Teacher fired for being unwed and pregnant can sue religious school, court rules
Josh Mitnick: Netanyahu's 'centrist' coalition is already proving it's anything but
Steven Goldberg: Earn Dividends in Emerging Markets with This WisdomTree ETF
Mary Beth Franklin: Retirement Savings Tips for New Grads
Amina Khan: Research links coffee to lower death rates
Chelsea Sheasley: Social media: Is it too feminine?
The Kosher Gourmet by Faith Duran : Cheesy Potato Breakfast Casserole with Cheddar and Sun-Dried Tomatoes
May 16, 2012
Jackson Holahan: The Aleppo Codex
Jonathan Tobin : Iran Declares Victory in Nuclear Talks
Anne Kates Smith: 7 Stocks That Let You Sleep Tight
Carmen Terzic, M.D., Ph.D. : Mayo Clinic Medical Edge: A variety of exercises can help improve balance
Melissa Healy: National strategy on Alzheimer's disease aims to halt it by 2025
The Kosher Gourmet by Joyce White : GOODNESS GRACIOUS: GREENS! 4 winning recipes that are no longer just for down-home folks (Includes expert tips & techniques)
May 15, 2012
Dennis Prager: God and Man at (and for) Liberty
Kristen Chick: Obama administration resumes arms sales to Bahrain despite serious unresolved human rights issues. Activists feel abandoned
Pat Mertz Esswein: Homes are now affordable again and mortgage rates are low. What you need to know before you buy
Kathy Kristof: Our Practical Investor Fights Inflation with These 6 Investments
Sue Hubbard, M.D.: The Kid's Doctor: Lactose intolerant young child? Check again
Environmental Nutrition Editors: Get the facts on palm sugar sweetening
The Kosher Gourmet by Kathy Hunt: Spread a Little Excitement with EXOTIC CONDIMENTS (4 RECIPES)
May 14, 2012
Richard Simon: Purple Hearts for domestic terror victims?
Nando Pelusi, Ph.D.: The privacy paradox: Surrounded by strangers, we risk isolation, anxiety
Chris Farrell: Investing Lessons from the Great Recession
Lisa Gerstner: How to Protect Your Identity, Finances If You Lose Your Phone
Harvard Health Letters: Heart disease and dementia
Tiffany O'Callaghan: New hormone mimics effects of exercise without the sweat
The Kosher Gourmet by Megan Gordon: MANGO COCONUT OAT MORNING MUFFINS are a bright but hearty delight
May 11, 2012
Rabbi B. Shafier: Why happiness will always be elusive
Charles Krauthammer: Echoes of '67: Israel unites
Howard LaFranchi: With G8 snub, US-Putin 'reset' off to stumbling start
Jeremy J. Siegel: Investors, Relax About Rising Interest Rates
Jessica L. Anderson: Get the Best Deal on a Used Car
Jett Stone: Forget face-lifts and fake knees. Scientists have seen the fountain of youth --- and it's broccoli
The Kosher Gourmet by Chef Mario Batali: The famed chef's vegetable dish that tastes true to the season: FAVAS AND SUGAR SNAP PEAS WITH POTATOES AND TARRAGON
May 10, 2012
Clifford D. May: The Real Palestinian Refugee Problem
Sergei L. Loiko: Putin sends warning to U.S., NATO in Victory Day speech at Red Square
Mary Rourke: How being a 'mentch' got Vidal Sasoon his start and fighting in Israel's War of Independence provided him with confidence and a strong sense of his own identity
Harvard Health Letters: Palliative care: Underused therapy yields surprising benefits
Jeff Bertolucci: Get Home Phone Service for Less Than $10 a Month
Rachel L. Sheedy and Susan B. Garland : Make the Right Moves to Boost Benefits
The Kosher Gourmet by Betty Rosbottom: Gleaming with its golden, crimson, and snowy white hues, this silken smooth and creamy STRAWBERRY ORANGE TRIFLE looks impressive, but is easy to prepare
May 9, 2012
John Rosemond: Parents, stop destroying the American male
Valerie J. Nelson: Maurice Sendak, author of 'Where the Wild Things Are,' dies at 83
Bob Frick: Angst Over Annuities
Sharon Palmer, R.D. How you can reduce your risk -- or delay -- chronic diseases associated with aging
Howard LeWine, M.D.: Ask the Harvard Experts: Why did my blood pressure suddenly shoot up?
Lisa Gerstner: Lower the Rate on All Your Loans
The Kosher Gourmet by Emily Ho : Springtime soba with miso sauce offers a coloful mix of fresh textures and flavors
May 8, 2012
Edmund Sanders: Netanyahu suddenly cancels new elections, forms unity government
Frank J. Gaffney Jr.: Farewell to European superstate
Anne Kates Smith: 4 Stocks That Mimic Buffett and Berkshire Hathaway
Gaia Vince and Clare Wilson The Rise of Miniature Medical Robots: Fantasy Fast Becoming Reality
Paul Takahashi, M.D.: Mayo Clinic Medical Edge: Never suffer night leg cramps
Jessica L. Anderson: Extended-Warranty Warning
The Kosher Gourmet by Diane Rossen Worthington: Celebrate National Chocolate Chip Day with the Best Cookie Ever (Includes techniques)
May 7, 2012
Mark Clayton: Homeland Security warns major cyber attack aimed at gas pipeline industry underway
Angus Roxburgh: Putin Decoded: World view of a Russian feeling dissed
Kimberly Lankford: Navigate a Course for Long-Term Care
Kevin McCormally How to Adjust Your Tax Withholding
Celeste Robb-Nicholson, M.D.: Harvard Health Letters: How do you treat a Baker's cyst?
Joanne Capano: Healthy Snacks for Children: The Choices May Surprise You
The Kosher Gourmet by Penelope Wall: Classic Creamy Spinach Dip with a Fraction of the Calories and Fat
May 4, 2012
Rabbi Nathan Lopes Cardozo: Holy 'trivialities'
Jonathan Tobin: Bibi v. Barak will be no contest this time around
Steven Goldberg: Blue Chip Stocks On Sale Worldwide
Art Pine Slow Productivity Growth a Blessing --- For Now
Sue Hubbard, M.D. : The Kid's Doctor: Are Kids Too Wired?
Kerri-Ann Jennings, M.S., R.D: Foods that are good for your smile
Amy Paturel, M.S., M.P.H.: Eating Well: Foods that are good for your smile
The Kosher Gourmet by Betty Rosbottom: Strawberry rhubarb parfaits are elegant yet simple to assemble
May 3, 2012
Michael Freund: Who's Afraid of the Messiah?
Clifford D. May: The Foggiest War
Susan B. Garland: Insurance to Cover Old Old Age
Steven Goldberg 6 Reasons to Bet on a Big Bull Market
Harvard Health Letters: Treating prostate cancer --- no rush to judgment
Larry Gordon: Harvard, MIT partner to offer free online courses
Naomi Nix : Man gets free trip to Chicago after postcard sent by mother in 1957 finally reaches him
The Kosher Gourmet by Diane Rossen Worthington: Intensely Italian vegetable frittata is a seriously simple standby


Jewish World Review

How Stuff Works: How vaccines work

By Marshall Brain

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http://www.JewishWorldReview.com | (MCT) accines are big news right now. All over town you can find places delivering the normal, seasonal flu vaccine — everywhere from the county health clinic to the local drugstore. There is also a lot of buzz around the special H1N1 vaccine — millions of people are being vaccinated. There is currently an outbreak of the mumps in Brooklyn, N.Y., and surrounding areas because people there weren't vaccinated properly.

At the root of all this is a simple and fascinating technology that takes advantage of a special property of the human immune system. We can understand how it works by looking at the world's first vaccine.

If we could go back in time to the 1700s, the world was a very different place. Infectious diseases ran rampant. Mumps, measles and polio were obvious problems, but there was also a scourge called smallpox. It killed millions. It left many people blind. And those who survived the disease were often left with disfiguring scars from the disease's pustules. These scars have been found on the faces of Egyptian mummies, so we know the disease is thousands of years old.

There was, however, a group of people who seemed to be untouched by smallpox. These people were known as milkmaids — women who milked cows for a living. Their immunity to smallpox was obvious because of their smooth skin. A scientist named Edward Jenner noticed this, and hypothesized that the women were being protected by exposure to cowpox. In other words, the women were getting infected with cowpox, which is a much milder disease than smallpox. Once the women recovered from cowpox, they had somehow acquired immunity to smallpox.

Jenner's breakthrough idea was this: If he were to purposefully infect people with cowpox at a young age, he would be able to protect them from smallpox for life. Jenner called the process vaccination — vacca being the Latin word for cow. James Phipps was the first boy to be vaccinated. Jenner made a small cut on his skin and inserted pus from a cowpox lesion. The boy did get sick with cowpox, and then recovered normally. And he became immune to smallpox in the process. The rest, as they say, is history. The process of vaccination was improved and refined, to the point where today the disease known as smallpox has been completely eradicated.

Why did this work? Jenner had no concept of the actual mechanisms. It would be more than 100 years before scientists discovered viruses. But the mechanism is the basis of all vaccines today. When a human being is infected by any viral disease, the human immune system has to discover and eliminate the virus. Virus particles are extremely small — much smaller than bacteria cells, which are themselves a hundred times smaller than human cells. The virus particles attach to human cells, inject a tiny bit of genetic material and force the cells to manufacture millions of new virus particles.

To eliminate a virus, white blood cells in your body produce antibodies. Antibodies are molecules that cling to virus particles and deactivate them. The clinging antibodies also act like beacons that make it easy for the body to eliminate the virus particles. However, the body does not make antibodies for a specific virus until it gets exposed to the virus. This is why most viral diseases are only caught once in a lifetime.

The idea behind any vaccine, therefore, is to pre-expose the body to a form of the virus so that the body is producing antibodies when the real virus comes along. In the case of smallpox, it turned out that the cowpox virus particles were nearly identical to smallpox virus particles — so close that cowpox antibodies also cling to smallpox virus particles. Once exposed to cowpox, the same antibodies would attack smallpox too. Other vaccines deliver dead virus particles. The body learns to produce antibodies against the dead virus, and then when it sees live virus particles it eliminates them immediately. All vaccines work on this same basic principle, exposing the immune system to the disease in some way so the body learns to produce antibodies. Those antibodies then confer protection against the real disease.

Are vaccines something to be afraid of? Obviously not. We should be far more fearful of the diseases they prevent. Vaccines have made our world a much better place, and when used widely can completely eliminate dangerous and deadly viruses.

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Previously:


How the smart grid works
How sea level works
How employee screening works
How to avoid catching a cold
How bread works
How a home energy audit works
How Omega-3 fatty acids work
Social networking
How trick birthday candles work
How electric cars like the Nissan Leaf work
How a manned mission to Mars works
How gold works
How bad breath works
How the ultimate sunglasses work
Any rocket is easily converted to a missile
How to have a great staycation
How a black box works
How a solar roof works
How nuclear bombs work
How the Hubble Space Telescope works
How hay fever works
How to know when to rent vs. buy
How swine flu works
How a kidney dialysis machine works
How children die in hot cars
How a trillion dollars works
How electronic cigarettes work
How chimpanzees work
How in vitro fertilization works
How supertankers work
How poisons work
How corn works
How dog ID chips work
How President Obama's limousine works
How emergency power works
How aircraft carriers work
How antibiotics and vaccines work
How mucus works
How iron and steel work
How aspirin works
How igloos work
How the Predator UAV works
How retention ponds work
How water absorbers work
How melamine works
How digital music works
How coal mining works
How an economic depression works
How the liver works
How 3D movies work
How oil pipelines work
How jet packs work
How seismographs work
How Olympic technology works
How Personal Rapid Transit works
How 3G works
How the Global Position System (GPS) works
How octane works
How cruise missiles work
How submarines work
How miles work
How octane works
How food preservation works
How beer works
How holding your breath works
How smoke detectors work
How heat pumps work
How your night vision works
How concentrating solar collectors work
How your key fob works
How the common cold works
How the Large Hadron Collider Works
How making a TV show works
How dry cleaning works
How exoskeletons work
How an oil refinery works
How landfills work
How the Orion spacecraft works
The cutting edge in HDTV
Redefining the CD
How the HDMI cable scam works
How glow-in-the-dark toys work
How the subprime mortgage crisis works
How gift cards work
How Tasers work
How giant TV screens work
How foreclosure works
How Air Force One works
How wildfire fighting works
How vitamins work
How ejection seats work
How reattaching limbs works
How hot air balloons work
How paparazzi work
How counterfeiting works
How CDs work
How the Edsel worked
How Stinger missiles work
How hybrid cars work
How sharks work
How mosquitoes work
How diesel engines work
How water towers work
How the Dawn mission works
How Kassam rockets work
How the North American Eagle works
Why aren't we flying to work?
How tofu and soy milk work
How Colony Collapse Disorder works
How airbags work
How the U.S. income tax works
How gum works
How caffeine works
How Daylight Saving Time works
How a cruise missile works
How snow making works

© 2007, How Stuff Works Inc. Distributed by McClatchy-Tribune Information Services.

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