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Jonathan Tobin: Defending the Right to a Jewish State

Heather Hale: Compliment your kids without giving them big heads

Megan Shauri: 10 ways you are ruining your own happiness

Carolyn Bigda: 8 Best Dividend Stocks for 2015

Kiplinger's Personal Finance editors: 7 Things You Didn't Know About Paying Off Student Loans

Samantha Olson: The Crucial Mistake 55% Of Parents Are Making At Their Baby's Bedtime

Densie Well, Ph.D., R.D. Open your eyes to yellow vegetables

The Kosher Gourmet by Megan Gordon With its colorful cache of purples and oranges and reds, COLLARD GREEN SLAW is a marvelous mood booster --- not to mention just downright delish
April 18, 2014

Rabbi Yonason Goldson: Clarifying one of the greatest philosophical conundrums in theology

Caroline B. Glick: The disappearance of US will

Megan Wallgren: 10 things I've learned from my teenagers

Lizette Borreli: Green Tea Boosts Brain Power, May Help Treat Dementia

John Ericson: Trying hard to be 'positive' but never succeeding? Blame Your Brain

The Kosher Gourmet by Julie Rothman Almondy, flourless torta del re (Italian king's cake), has royal roots, is simple to make, . . . but devour it because it's simply delicious

April 14, 2014

Rabbi Dr Naftali Brawer: Passover frees us from the tyranny of time

Greg Crosby: Passing Over Religion

Eric Schulzke: First degree: How America really recovered from a murder epidemic

Georgia Lee: When love is not enough: Teaching your kids about the realities of adult relationships

Cameron Huddleston: Freebies for Your Lawn and Garden

Gordon Pape: How you can tell if your financial adviser is setting you up for potential ruin

Dana Dovey: Up to 500,000 people die each year from hepatitis C-related liver disease. New Treatment Has Over 90% Success Rate

Justin Caba: Eating Watermelon Can Help Control High Blood Pressure

The Kosher Gourmet by Joshua E. London and Lou Marmon Don't dare pass over these Pesach picks for Manischewitz!

April 11, 2014

Rabbi Hillel Goldberg: Silence is much more than golden

Caroline B. Glick: Forgetting freedom at Passover

Susan Swann: How to value a child for who he is, not just what he does

Cameron Huddleston: 7 Financial Tasks You Should Tackle Right Now

Sandra Block and Lisa Gerstner: How to Profit From Your Passion

Susan Scutti: A Simple Blood Test Might Soon Diagnose Cancer

Chris Weller: Have A Slow Metabolism? Let Science Speed It Up For You

The Kosher Gourmet by Diane Rossen Worthington Whitefish Terrine: A French take on gefilte fish

April 9, 2014

Jonathan Tobin: Why Did Kerry Lie About Israeli Blame?

Samuel G. Freedman: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Jessica Ivins: A resolution 70 years later for a father's unsettling legacy of ashes from Dachau

Kim Giles: Asking for help is not weakness

Kathy Kristof and Barbara Hoch Marcus: 7 Great Growth Israeli Stocks

Matthew Mientka: How Beans, Peas, And Chickpeas Cleanse Bad Cholesterol and Lowers Risk of Heart Disease

Sabrina Bachai: 5 At-Home Treatments For Headaches

The Kosher Gourmet by Daniel Neman Have yourself a matzo ball: The secrets bubby never told you and recipes she could have never imagined

April 8, 2014

Lori Nawyn: At Your Wit's End and Back: Finding Peace

Susan B. Garland and Rachel L. Sheedy: Strategies Married Couples Can Use to Boost Benefits

David Muhlbaum: Smart Tax Deductions Non-Itemizers Can Claim

Jill Weisenberger, M.S., R.D.N., C.D.E : Before You Lose Your Mental Edge

Dana Dovey: Coffee Drinkers Rejoice! Your Cup Of Joe Can Prevent Death From Liver Disease

Chris Weller: Electric 'Thinking Cap' Puts Your Brain Power Into High Gear

The Kosher Gourmet by Marlene Parrish A gift of hazelnuts keeps giving --- for a variety of nutty recipes: Entree, side, soup, dessert

April 4, 2014

Rabbi David Gutterman: The Word for Nothing Means Everything

Charles Krauthammer: Kerry's folly, Chapter 3

Amy Peterson: A life of love: How to build lasting relationships with your children

John Ericson: Older Women: Save Your Heart, Prevent Stroke Don't Drink Diet

John Ericson: Why 50 million Americans will still have spring allergies after taking meds

Cameron Huddleston: Best and Worst Buys of April 2014

Stacy Rapacon: Great Mutual Funds for Young Investors

Sarah Boesveld: Teacher keeps promise to mail thousands of former students letters written by their past selves

The Kosher Gourmet by Sharon Thompson Anyone can make a salad, you say. But can they make a great salad? (SECRETS, TESTED TECHNIQUES + 4 RECIPES, INCLUDING DRESSINGS)

April 2, 2014

Paul Greenberg: Death and joy in the spring

Dan Barry: Should South Carolina Jews be forced to maintain this chimney built by Germans serving the Nazis?

Mayra Bitsko: Save me! An alien took over my child's personality

Frank Clayton: Get happy: 20 scientifically proven happiness activities

Susan Scutti: It's Genetic! Obesity and the 'Carb Breakdown' Gene

Lecia Bushak: Why Hand Sanitizer May Actually Harm Your Health

Stacy Rapacon: Great Funds You Can Own for $500 or Less

Cameron Huddleston: 7 Ways to Save on Home Decor

The Kosher Gourmet by Steve Petusevsky Exploring ingredients as edible-stuffed containers (TWO RECIPES + TIPS & TECHINQUES)

Jewish World Review

Time to reconsider estrogen-only therapy?

By Shari Roan




A new analysis, released yesterday, from a federally-funded trial offers a more complete picture

http://www.JewishWorldReview.com | (MCT) Although many women have sworn off hormone therapy, a new analysis from the clinical trial that first unearthed the hormones' risks shows taking estrogen alone for menopausal symptoms, even for several years, may be safer than first thought.

The new finding — the latest from the Women's Health Initiative, a federally funded trial that tracked thousands of women taking hormones or placebo pills for years — looked at women who have had hysterectomies and thus can take estrogen unaccompanied by another hormone, progestin. (Women with a uterus take progestin to protect against uterine cancer.) It found that a heightened risk of stroke from taking estrogen faded with time, while a reduced risk of breast cancer held steady.

That news, published Tuesday in the Journal of the American Medical Association, may weaken — for this group of women — the current recommendation from doctors that hormones to treat hot flashes and other menopausal symptoms should be taken in the smallest doses possible for the shortest amount of time.

"This study is very good news for women without a uterus," said Andrea LaCroix, the lead author of the study and an epidemiologist at the Fred Hutchinson Cancer Research Center in Seattle.

The so-called estrogen-only arm of the Women's Health Initiative, which began with more than 10,000 women ages 50 to 79 who'd had a hysterectomies, was halted prematurely in 2004 after researchers discovered that the risk of stroke was slightly higher — 12 more cases among 10,000 people — in women who had taken estrogen for an average of six years compared with those who received placebo pills. At the same time, the hormone failed to reduce the risk of heart disease, which had been the principal hope of the study.


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LaCroix and her colleagues examined data from 7,645 of the participants more than four years after they had stopped therapy. The scientists found that a slightly higher risk of blood clots in the legs, corresponding to six additional cases per 10,000 women, vanished along with the increased risk of stroke. So too did a benefit: A small decreased risk of hip fracture seen during the intervention — six fewer hip fractures per 10,000 women — returned to baseline after the women stopped taking estrogen.

"What's very interesting is the fact that the reduction of breast cancer in this particular group persisted while all the other risks and benefits disappeared," said Dr. Margery Gass, executive director of the North American Menopause Society and a consultant at the Cleveland Clinic, who was not involved in this particular Women's Health Initiative report. "It's very hard to explain."

Estrogen is thought to promote breast cancer in some women by stimulating cell growth and inhibiting the natural suicide of cells, a process called apoptosis. Other research, however, has hinted that a period of years with no hormones — such as natural menopause — followed by a period of hormone exposure produces anti-cancer effects.

"In these circumstances, estrogen acts like it stimulates apoptosis," said Dr. Rowan T. Chlebowski, a medical oncologist at the Los Angeles Biomedical Research Institute and a co-author of the study. By so doing, it could cause precancerous cells in the breast to self-destruct before they cause problems. He called the finding on breast cancer risk reduction "definitive."

The analysis also sheds some light on whether the risks and benefits of taking of estrogen differ depending on a woman's age. Some have criticized the Women's Health Initiative because many of the participants were age 60 or older when the study began. In normal medical settings, women begin taking hormones for relief of symptoms such as hot flashes that occur at the time of menopause, which for most women is in their early 50s. The safety profile for the younger women appeared better than for older women in the study, LaCroix and her colleagues reported: The younger women were less likely to have heart attacks or die from other diseases. Based on these findings, the scientists calculated that if 10,000 women ages 50 to 59 took estrogen for 10 years and seven months, there would be 12 fewer acute heart attacks, 13 fewer deaths from any cause and 18 fewer adverse events related to chronic diseases, such as diabetes, compared with women taking placebo pills.

In contrast, in 10,000 women ages 70 to 79, there would be 16 more heart attacks, 19 more deaths and 48 more adverse events related to chronic diseases compared with women taking placebos.

"Six years of use followed by stopping appears to be very safe for younger women, with the exception of blood clots," LaCroix said. "But for women in their 70s, this does not appear to be a safe medicine."

It's unlikely that the study will reignite women's passion for hormones, said researchers from Washington University School of Medicine in St. Louis in an editorial accompanying the study. Prescriptions have plummeted in the last seven years as hopes were dashed that hormone therapy would generally improve women's health in the later part of life.

"Instead of women taking a pill they thought was going to protect against heart disease and osteoporosis and all these other effects, you now offer a pill that has benefits and risk that equal out," said Dr. Graham Colditz, a co-author of the editorial. "Most people aren't going to run out to take something that may cause them to have a stroke."

But other experts said the persistent reduction in breast cancer risk needs to be explored further in research.

"The effects on breast cancer risk are much different than people thought," Chlebowski said. "There are time-dependent and exposure-dependent effects that are complicated and aren't well understood."

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© 2011, Los Angeles Times. Distributed by McClatchy-Tribune Information Services.